CSFĬoncentrations of free and conjugated norepinephrine and epinephrine, 3-methoxy-4-hydroxyphenylglycol,Īnd homovanillic acid were unchanged after the transplantation. TheĬoncentrations of sulfoconjugated but not free dopamine were modestly increased inĬSF after the transplantation, although plasma concentrations were unchanged. The major fractions of the Catecholamines in CSF were suite-conjugated. (CSF) and plasma 1 hour after the patients' first morning dose of l-dopa. Were also measured, before and after transplantation, in lumbar cerebrospinal fluid Medulla but were barely detectable in caudate nucleus. Were some 600 times and 90 times higher, respectively, than that of dopamine in adrenal The caudate and the adrenal medulla epinephrine and noreplnephrine concentrations Dopamine concentrations were quite similar in High-performance liquid chromatography with electrochemical detection was Medulla in eight patients with Parkinson's disease who were taking l-dopa and were undergoing autologous transplantation of adrenal medulla to caudate Catecholamine concentrations were measured in tissue samples of caudate and adrenal
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